Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Tylenol And Glutathione Invigor Medical Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Acetaminophen Intoxication: A Critical Care Emergency Sex differences in glutathione metabolism and acetaminophen toxicity Acetaminophen toxicity EMCrit Project