Melanosis coli: Symptoms, causes, treatment, and more MELANOSIS COLI** Melanosis coli is a disorder of pigmentation of the bowel wall. Histology demonstrates pigment laden macrophages It is associated with laxative abuse, especially **anthraquinone compounds such as senna** ICD 10 Coding for Loose Bowel Movements Melanosis Ilei Clinical Gastroenterology and Hepatology Melanosis coli is dark brown black pigmentation of colorectal mucosa associated with chronic use of laxatives containing anthraquinone. Examples of such laxatives include senna and rhubarb derivatives. Clinical Importance: There is no association Benign Discoloration Poses Questions