Hydrogen Water vs. Glutathione Reductase (GR): Which Is Better? Evolved H2O Schematic representation of the role of the glutathione reductase enzyme. Download Scientific Diagram G6PD Deficiency Causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Correcting glucose 6 phosphate dehydrogenase deficiency with a small molecule activator Nature Communications